What is CJC-1295 No DAC? A Researcher's Guide to the GHRH Analogue

CJC-1295 No DAC (also known as Mod GRF 1-29) is a synthetic analogue of the first 29 amino acids of growth hormone-releasing hormone (GHRH). It is one of the most widely used GHRH analogues in research, valued for its ability to stimulate pulsatile growth hormone (GH) release in a physiologically relevant manner without the prolonged half-life associated with the DAC (Drug Affinity Complex) version.

What is CJC-1295 No DAC?

CJC-1295 No DAC corresponds to GHRH(1-29) with four amino acid substitutions that enhance stability against enzymatic degradation — specifically protecting against DPP-IV and other proteases that rapidly degrade native GHRH. The ‘No DAC’ designation distinguishes it from CJC-1295 with DAC, which incorporates a lysine-reactive maleimide group that enables covalent albumin binding and dramatically extends half-life.

Its primary receptor target is:

  • GHRH receptor (GHRHR) — expressed on anterior pituitary somatotrophs; activation stimulates pulsatile GH secretion

Mechanism of Action

CJC-1295 No DAC acts as a GHRHR agonist, stimulating pulsatile GH release from the pituitary in a pattern that mirrors endogenous GHRH activity. Its moderate half-life (approximately 30 minutes) means it produces a defined GH pulse rather than sustained GH elevation, making it particularly useful for research models where physiological GH pulsatility is important.

It is frequently combined with GHSR agonists (such as Ipamorelin) in research protocols to investigate synergistic GH release through dual pathway activation.

Why CJC-1295 No DAC is of Research Interest

CJC-1295 No DAC's ability to produce physiological GH pulses makes it a versatile research tool. Key areas of ongoing research include:

  • GH/IGF-1 axis modulation and somatopause research
  • Pulsatile vs. sustained GH release comparative studies
  • Muscle and bone metabolism research
  • Body composition and adipose tissue studies
  • Combined GHRH + GHSR agonist synergy research
  • Sleep quality and GH pulsatility studies

CJC-1295 No DAC vs. CJC-1295 with DAC

The key distinction for research design:

  • CJC-1295 No DAC — half-life ~30 minutes; produces defined GH pulses; preferred for physiological pulsatility research
  • CJC-1295 with DAC — half-life ~7–8 days via albumin binding; produces sustained GH elevation; preferred for studies requiring prolonged GH axis activation

Sourcing CJC-1295 No DAC for Research

Research-grade CJC-1295 No DAC should be sourced from suppliers providing batch-specific Certificates of Analysis (CoA) confirming purity (>98%), identity, and potency. Lyophilised formats offer optimal stability for laboratory storage.

At Aura Peptides, our CJC-1295 No DAC is supplied as a research-grade lyophilised peptide with full CoA documentation, available as single vials or in 10x bulk packs for high-volume research programmes.

For research purposes only. Not intended for human or veterinary use.

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